The main station is the largest train station in Prague. The Art Nouveau complex was designed by Josef Fanta, as visitors are reminded by the posh Fanta's Café (Fantova kavárna) upstairs. The station building was completed in 1909 and opened as the Franz Josef Station. It was later renamed to Wilson Station (Wilsonovo nádraží) after Woodrow Wilson and today is referred to as the Main Station (hlavní nádraží).

The building with its cupola-shaped, richly decorated lobby, statues, wrought-iron elements, and steel and glass construction above the tracks is  a  valuable  work  of  Czech  architecture.

The easiest way to get to the station is to take line C of the metro to Hlavní nádraží.