With its size of 80 552 m², Karlovo náměstí is the largest square in the Czech Republic and one of the largest squares in Europe. It was originally built as the Cattle Market. Its two most notable buildings are the New Town Hall (Novoměstská radnice) where Prague's first defenestration took place in 1419, and the Baroque Jesuit Church of Saint Ignatius from 1671. The 16th century Faust's House stands near the southwest corner of the square.

To get to Karlovo náměstí, you can take line B of the metro or tram 3, 4, 6, 10, 14, 16, 18, 22 or 24 to Karlovo náměstí.